Integrated Structural Biology Approach for Membrane Protein Research
Rome 3^rd and 4^th March 2022

Sapienza University of Rome, Aula degli Organi Collegiali

Proteins are the functional macromolecules in cells, they are the main drug targets and also used as pharmaceuticals and in biotechnology. Notably, nearly 30% of proteins in eukaryotic cells are known to be membrane proteins.

Although most commercial drugs result from conventional discovery methods, it is the structural information provided by three-dimensional protein structures that unveils the crucial structural arrangement and atomic interactions in drug-protein complexes. This information is critical in the rational design of new drugs with improved selectivity and pharmaceutical properties.

The Workshop will cover advanced methods for the characterization of membrane proteins with a specific focus on drug targets and rational drug design and new structures of membrane proteins.

The main topics will be:
Latest developments in Methods & Facilities
Membrane Proteins functional studies
Structures of membrane proteins relevant for understanding pathologies and drugs design.

Speakers are leading experts in the field from several Academic Institutions (New York Structural Biology Center, Columbia University, Imperial College, IME-Fraunhofer, ITQB-Universidade Nova de Lisboa, Basel Biozentrum, Naples Tigem, Milan University, Pavia University, Calabria University and SME Calixar In France). The Workshop is organized in the context of the the Prometeus MSCA-RISE Project.

Online Attendance Attendance in Person

Watch Day 1 Watch Day 2

PROGRAMME

Registration at Aula degli Organi Collegiali starts on March 3^rd, 2022 at 13:30

Day 1 – March 3^rd, 2022
Sapienza University of Rome, Aula degli Organi Collegiali

14:00-14:05	OPENING Beatrice Vallone Sapienza University of Rome

14:00-14:05	OPENING Beatrice Vallone Sapienza University of Rome

Session 1: Latest developments in Methods & Facilities

Chair Paolo Mariani · UNIVPM (Ancona, Italy)

14:10-14:40	Brian Kloss NYSBC (New York, USA) Membrane protein structural genomics at COMPPÅ past and present
14:40-15:10	Alexis Moreno Calixar (Lyon, France) Native membrane proteins for drug discovery
15:10-15:40	Bernadette Byrne Imperial College (London, UK) New approaches to working with membrane proteins
15:40	Coffee Break

14:10-14:40	Brian Kloss NYSBC (New York, USA) Membrane protein structural genomics at COMPPÅ past and present
14:40-15:10	Alexis Moreno Calixar (Lyon, France) Native membrane proteins for drug discovery
15:10-15:40	Bernadette Byrne Imperial College (London, UK) New approaches to working with membrane proteins
15:40	Coffee Break

Session 2: Membrane Proteins in Pharmacology and Disease

Chair Alberto Boffi · Sapienza University of Rome

16:10-16:40	Antonella De Matteis Tigem (Naples, Italy) Membrane remodelling: lessons from coronaviruses
16:40-17:10	Cesare Indiveri Calabria University (Arcavacata di Rende, Italy) Membrane transporters and novel targets in drug discovery
17:10-17:40	Bjoern Windshuegel IME-Fraunhofer (Hamburg, Germany) Computational Approaches for Early Stage Drug Discovery
20:00	Workshop Dinner

16:10-16:40	Antonella De Matteis Tigem (Naples, Italy) Membrane remodelling: lessons from coronaviruses
16:40-17:10	Cesare Indiveri Calabria University (Arcavacata di Rende, Italy) Membrane transporters and novel targets in drug discovery
17:10-17:40	Bjoern Windshuegel IME-Fraunhofer (Hamburg, Germany) Computational Approaches for Early Stage Drug Discovery
20:00	Workshop Dinner

Day 2 – March 4^th, 2022
Sapienza University of Rome, Aula degli Organi Collegiali

8:55-9:00	OPENING Francesco Malatesta Sapienza University of Rome

8:55-9:00	OPENING Francesco Malatesta Sapienza University of Rome

Session 3: Structural session – The prokaryotic world

Chair Linda C. Montemiglio · CNR – IBPM (Rome, Italy)

9:00-9:30	Filippo Mancia Columbia University (New York, USA) Structural basis of lipopolysaccharide biosynthesis
9:30-10:00	Margarida Archer ITQB-UNL (Lisbon, Portugal) The intricate mode of action of arabinofuranosyltransferases in mycobacteria
10:00-10:30	Camilo Perez Biozentrum (Basel, CH). Mechanism of Cell Wall Transporters Involved in Teichoic Acids Synthesis
10:30	Coffee Break

9:00-9:30	Filippo Mancia Columbia University (New York, USA) Structural basis of lipopolysaccharide biosynthesis
9:30-10:00	Margarida Archer ITQB-UNL (Lisbon, Portugal) The intricate mode of action of arabinofuranosyltransferases in mycobacteria
10:00-10:30	Camilo Perez Biozentrum (Basel, CH). Mechanism of Cell Wall Transporters Involved in Teichoic Acids Synthesis
10:30	Coffee Break

Session 4: Structural session – The eukaryotic world

Chair Beatrice Vallone · Sapienza University of Rome

11:00-11:30	Francesca Vallese Columbia University (New York, USA) Architecture of the human erythrocyte ankyrin-1 complex
11:30-12:00	Francesca Magnani Pavia University (Pavia, Italy) Structure determination of membrane proteins, from GPCRs to the elusive NADPH oxidases and solute carriers
12:00-12:30	Anna Moroni Milano University (Milan, Italy) Vidēre est credere: the high resolution structure of the pacemaker channel HCN4
12:30-13:00	Discussion & Remarks

11:00-11:30	Francesca Vallese Columbia University (New York, USA) Architecture of the human erythrocyte ankyrin-1 complex
11:30-12:00	Francesca Magnani Pavia University (Pavia, Italy) Structure determination of membrane proteins, from GPCRs to the elusive NADPH oxidases and solute carriers
12:00-12:30	Anna Moroni Milano University (Milan, Italy) Vidēre est credere: the high resolution structure of the pacemaker channel HCN4
12:30-13:00	Discussion & Remarks

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