Prometeus International Conference
The main scientific and technological results of the Prometeus Project are going to be presented in this Conference, along with selected talks of international experts in the field of membrane proteins and protein methods and technologies.
Registration
Register for the Conference by filling out the form. Upon completion of registration you will receive the Zoom link to participate online.
Sessions
1. Compound screening and synthesis for ligand design & protein stabilization (10:00-11:30)
Chair: A. Boffi (MoLiRom, Rome, Italy)
| 10:00 – 10:20 | Synthesis of (oligo)arabinosides and development of a functional assay for the study of enzymes involved in cell wall biosynthesis R. Ventura Extremochem, Oeiras (Portugal) |
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| 10:20 – 10:40 | Virtual screening in early stage drug discovery B. Windshugel Fraunhofer ITMP Discovery Research ScreeningPort, Hamburg (Germany) |
| 10:40 – 11:00 | Novel solvents in protein chemistry A. Boffi MoLiRom, Rome (Italy) |
| 11:00 – 11:30 | General discussion |
| 10:00 – 10:20 | Synthesis of (oligo)arabinosides and development of a functional assay for the study of enzymes involved in cell wall biosynthesis R. Ventura Extremochem, Oeiras (Portugal) |
| 10:20 – 10:40 | Virtual screening in early stage drug discovery B. Windshugel Fraunhofer ITMP Discovery Research ScreeningPort, Hamburg (Germany) |
| 10:40 – 11:00 | Novel solvents in protein chemistry A. Boffi MoLiRom, Rome (Italy) |
| 11:00 – 11:30 | General discussion |
2. Strategies for protein production and stabilization (13:00-14:30)
Chair P. Mariani (Università Politecnica delle Marche, Ancona, Italy)
| 13:00 – 13:20 | Cloning, expression and purification of human recombinant paraoxonase-2 enzyme for structural purpose D. Sartini Università Politecnica delle Marche, Ancona (Italy) |
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| 13:20 – 13:40 | Expression and Purification of SRD5A membrane enzymes G. Parisi Sapienza University of Rome (Italy) |
| 13:40 – 14:00 | Small-Angle Neutron Scattering of Liposomes embedded with OprF Porins of Pseudomonas aeruginosa F. Spinozzi Università Politecnica delle Marche, Ancona (Italy) |
| 14:00 – 14:30 | General discussion |
| 13:00 – 13:20 | Cloning, expression and purification of human recombinant paraoxonase-2 enzyme for structural purpose D. Sartini Università Politecnica delle Marche, Ancona (Italy) |
| 13:20 – 13:40 | Expression and Purification of SRD5A membrane enzymes G. Parisi Sapienza University of Rome (Italy) |
| 13:40 – 14:00 | Small-Angle Neutron Scattering of Liposomes embedded with OprF Porins of Pseudomonas aeruginosa F. Spinozzi Università Politecnica delle Marche, Ancona (Italy) |
| 14:00 – 14:30 | General discussion |
3. Protein Structure and Function (15:00-16:50)
Chair: B. Vallone (Sapienza University of Rome, Italy)
| 15:00 – 15:20 | Structural and functional studies of mycobacterial glycosyltransferases M. Archer ITQB-NOVA, Oeiras (Portugal) |
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| 15:20 – 15:40 | 3-O-methyltolcapone and Its Lipophilic Analogues are Potent Inhibitors of Transthyretin Amyloidogenesis with High Permeability and Low Toxicity M. Cianci Università Politecnica delle Marche, Ancona (Italy) |
| 15:40 – 16:00 | Structural basis of dimerization of chemokine receptors CCR5 and CXCR4 D. Di Marino Università Politecnica delle Marche, Ancona (Italy) |
| 16:00 – 16:20 | Peering into the allosteric regulation of the ryanodine receptor with cryoEM A .Des Georges New York University, New York (USA) |
| 16:20 – 16:50 | General discussion |
| 15:00 – 15:20 | Structural and functional studies of mycobacterial glycosyltransferases M. Archer ITQB-NOVA, Oeiras (Portugal) |
| 15:20 – 15:40 | 3-O-methyltolcapone and Its Lipophilic Analogues are Potent Inhibitors of Transthyretin Amyloidogenesis with High Permeability and Low Toxicity M. Cianci Università Politecnica delle Marche, Ancona (Italy) |
| 15:40 – 16:00 | Structural basis of dimerization of chemokine receptors CCR5 and CXCR4 D. Di Marino Università Politecnica delle Marche, Ancona (Italy) |
| 16:00 – 16:20 | Peering into the allosteric regulation of the ryanodine receptor with cryoEM A .Des Georges New York University, New York (USA) |
| 16:20 – 16:50 | General discussion |
